About laboratory

Lipids are important nutrients for various biological reactions. Recent epidemiological evidence suggests that dietary consumption of some lipid molecules may modify the risk for certain disorders. However, the molecular basis of their actions is still to be clarified. Since most of the lipids are hydrophobic, they are solubilized and transported within the cells to exert their cellular functions by specific intracellular lipid binding proteins, the low molecular mass polypeptides of 14-15 kDa termed fatty acid binding proteins (FABPs). FABPs bind to long chain fatty acids, being involved in the promotion of cellular uptake and transport of fatty acids, the targeting of fatty acids to specific metabolic pathways, and the regulation of gene expression. The major goal of our laboratory is to clarify the molecular basis of the interactions between lipids and a number of physiological responses by focusing on the biological role of intracellular lipid binding proteins, and to explore the link between cellular lipid homeostasis and human diseases such as schizophrenia and liver fibrosis.

What's new

Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease (Kikuchi et al., Nat Commun)
Article on The role of fatty acid binding protein 7 in spinal cord astrocytes in a mouse model of experimental autoimmune encephalomyelitis (Kamizato et al., Neurosci)
Article on Evaluation of the role of fatty acid binding protein 7 in controlling schizophrenia-relevant phenotypes using newly established knockout mice (Shimamoto-Mitsuyama et al., Schizophr Res)
Article on FABP7 protects astrocytes against ROS toxicity via lipid droplet formation (Islam et al., Mol Neurobiol)
Article on FABP3 in the anterior cingulate cortex modulates the methylation status of the glutamic acid decarboxylase67 promoter region (Yamamoto et al., J Neurosci;Topics)
Review article on Role of FABP7 in tumor cell signaling (Kagawa et al., Adv Biol Reg)
Article on Down-regulation of fatty acid binding protein (Fabp7) is a hallmark of the postpartum brain (Collaboration with Wisconsin-Madison Univ)
Article on Glial fatty acid binding protein (FABP7) regulates neuronal leptin sensitivity in the hypothalamic arcuate nucleus (Yasumoto et al., Mol Neurobiol; Topics)
Article on Origin and development of septoclasts in endochondoral ossification of mice (Collaboration with Meikai Univ)
Article on Dab1 contributes differently to the morphogenesis of the hippocampal subdivisions (Collaboration with Shiga Medical Univ)
Article on Mitochonic acid 5 (MA-5) facilitates ATP synthase oligomerization and cel survial in mitochondria diseases (Collaboration with Department of Nephrology, Endocrinology and Vascular Medicine, Tohoku Univ)
Article on Ramelteon improves post-traumatic stress disorder-like behaviors exhibited by fatty acid-binding protein 3 null mice (Collaboration with Graduate School of Pharmaceutical Science, Tohoku Univ)
Article on Retinoic acid regulates cell-shape and -death of E-FABP(FABP5)-immunoreactive septoclasts in the growth plate cartilage of mice (Collaboration with Meikai Univ)
Article on Normal spleep requires the astrocyte brain-type fatty acid binding protein FABP7(Collaboration with Washington State Univ)
Article on Microglia-derived neuregulin expression in psychiatric disorders (Collaboration with Nara Medical Univ)
Article on Infection programs sustained lymphoid stromal cell responses and shapes lymph node remodeling upon secondary challenge (Collaboration with Melbourne Univ)
Article on Fatty acid-binding protei 5 at the blood-brain barrier regulates endogenous brain docosahexaenoic acid levels and cognitive function (Collaboration with Monash Univ)
Article on Ultrastructural histometric evidence for expansion of the sustentacular cell envelop in response to hypersecretion of adrenal chromaffin cells in mice (Collaboration with Khon Kean Univ)
Article on Characterization of fatty acid binding protein 7 (FABP7) in the murine retina (Collaboration with Missouri Univ)
Review article on Gamma/delta intraepithelial lymphocytes in the mouse intestine.
Article on Modulation of anti-cancer drug sensitivity through the regulation of mitochondorial activity by adenylate kinase 4 (Collaboration with Yamaguchi Univ
Article on Inhibition of fatty acid synthase decreases expression of stemness markers in glioma stem cells (Yasumoto et al., Plos One; Topics)
Article on Dorsal forebrain-specific deficiency of Reelin-Dab1 signal causes behavioral abnormalities related to psychiatric disorders (Imai et al, Cereb Cortex; Topics
Article on Investigation of the fatty acid transporter-encoding genes SLC27A3 and SLC27A4 in autism (Collaboration with RIKEN BSI)
Article on Fatty acid-binding protein 5 facilitates the blood-brain barrier transport of docosahexaenoic acid (Collaboration with Monash Univ)
Article on Fatty acid binding protein deletion suppresses inflammatory pain through endocannabinoid/N-acylethanolamine-dependent mechanisms (Collaboration with New York State Univ)
Article on Astrocyte- expressed Fabp7 regulates dendritic morphology and excitatory synaptic function of cortical neurons (Ebrahimi et al, Glia; Topics
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